The Role of Il-17 in Regulating Liver Macrophage Permissiveness for Leishmania Infection

Grant number: 1105817 | Funding period: 2017 - 2019

Completed

Abstract

Visceral Leishmaniasis is a disease of poverty in the developing world caused by Leishmania parasites, which live and replicate within host tissue macrophages. A cytokine produced by host cells, IL-17A impairs the ability of liver macrophages to control this infection, as mice that lack IL-17A have lower parasite burdens in the liver after experimental infection. We propose to investigate if IL-17A mediates this impaired control by tuning the permissiveness of host macrophages to infection.

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